manuscripts  :: Published - 3D MRI of non-Gaussian 3He gas diffusion in the rat lung :: (1647 Reads)

Posted by mak on Monday, October 22, 2007 - 11:58 PM

Jacob RE, Laicher G, and Minard KR. (2007). 3D MRI of Non-Gaussian 3He Gas Diffusion in the Rat Lung. J Magn Reson. 188, 357-366.

In 3He magnetic resonance images of pulmonary air spaces, the confining architecture of the parenchymal tissue results in a non-Gaussian distribution of signal phase that non-exponentially attenuates image intensity as diffusion weighting is increased. Here, two approaches previously used for the analysis of non-Gaussian effects in the lung are compared and related using diffusion-weighted 3He MR images of mechanically ventilated rats. One approach is model-based and was presented by Yablonskiy et al., while the other approach utilizes the second order decay contribution that is predicted from the cumulant expansion theorem. Total lung coverage is achieved using a hybrid 3D pulse sequence that combines conventional phase encoding with sparse radial sampling for efficient gas usage. This enables the acquisition of nine 3D images using a total of only 1 L of hyperpolarized 3He gas. Diffusion weighting ranges from 0 s/cm2 to 40 s/cm2. Results show that the non-Gaussian effects of 3He gas diffusion in healthy rat lungs are directly attributed to the anisotropic geometry of lung microstructure as predicted by the Yablonskiy model, and that quantitative analysis over the entire lung can be reliably repeated in time-course studies of the same animal.