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Project Synopsis
| The overall objective of this research is to
develop state-of-the-art, biologically-based
computational models of the respiratory system
that couples high-performance supercomputing with
the latest imaging and experimental
advances. Using an interdisciplinary
bioengineering approach, we hope to achieve an
unprecedented level of detail in describing
structure-function relationships in the
respiratory system of laboratory animals and
humans. Our underlying philosophy centers on the
belief that highly detailed biologically based
computational models provide a unique basis for
integrating fundamental information about the
mammalian respiratory system into a quantitative,
understandable format that can readily be
interrogated to gain important new insights into
how interactions with the environment ultimately
affect both normal and potentially sensitive
individuals. |
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Reconstructed Airway Tree
| Magnetic resonance imaging of hyperpolarized 3-He
was used to create this 3D image of an airway
tree. The imaging was done on a live,
mechanically ventilated, 310 g rat. The airway
tree is rotated such that the trachea is vertical,
as if the rat was standing on his hind legs. |
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Published - 3D MRI of non-Gaussian 3He gas diffusion in the rat lung
Posted by
mak
on
Oct 22, 2007
— 416 views
Manuscript List and Links
Posted by
mak
on
Jun 14, 2007
— 387 views
We've moved!
Posted by
mak
on
Feb 06, 2007
— 213 views
Abstract: Quantitative Magnetic Resonance Imaging of 3-He Gas Transport
R.E. Jacob and K.R. Minard, "Quantitative Magnetic Resonance Imaging of 3-He Gas Transport", American Physical Society March Meeting, Denver, CO. March 5-9, 2007.
Posted by
rejacob
on
Nov 20, 2006
— 273 views
Abstract: New technologies for constructing and confirming computational...
Corley RA, Minard KR, Jacob R, Einstein DR, Kuprat AP, Kabilan S, Timchalk C, Trease LL, Fowler J, Asgharian B, Wong BA, and Kimbell JS. (2006). New technologies for constructing and confirming computational fluid dynamics models of respiratory drug delivery. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. San Antonio, TX. October 29-November 2, 2006.
Posted by
mak
on
Nov 06, 2006
— 294 views
Submitted: The impact of breathing pattern and lung size on the alcohol...
Hlastala MP and Anderson JC (2006) The impact of breathing pattern and lung size on the alcohol breath test. J Appl Physiol. (Submitted).
Posted by
mak
on
Nov 06, 2006
— 291 views
Accepted: Characteristics of airflow in a CT-based ovine lung...
Kabilan S, Lin CL, and Hoffman EA. (2006) Characteristics of airflow in a CT-based ovine lung: a numerical study. J Appl Physiol. (Accepted).
Posted by
mak
on
Nov 06, 2006
— 278 views
Published: Modeling oxygen and carbon dioxide transport and exchange in a closed
Carlson BE, Anderson JC, Raymond GR, Dash RK, and Bassingthwaighte JB. (2008) Modeling oxygen and carbon dioxide transport and exchange in a closed-circulatory system. Oxygen Transport to Tissue XXIX. 614: 353-360.
Read full article: 184 more words
Posted by
mak
on
Oct 31, 2006
— 336 views
Abstract: Magnetic resonance imaging and computational fluid dynamic (CFD)...
Timchalk C, Minard KR, Jacob RE, Trease HE, Einstein DR, Trease LL, Kabilan S, and Corley RA. (2005). Magnetic resonance imaging and computational fluid dynamic (CFD) modeling of the rat respiratory system: Mesh development, airflow dynamics and particulate matter deposition. Frontiers in Aerosol Dosimetry Research Conference. Irvine, CA. October 24-25, 2005
Posted by
rejacob
on
Oct 31, 2006
— 273 views
Abstract: Particokinetics and the development of virtual respiratory system models
Corley RA, Minard KR, Jacob RE, Einstein DR, Kuprat AP, Kabilan S, Trease LL, Teeguarden JG, Robertson HT, Asgharian B, and Timchalk C. (2006) Particokinetics and the development of virtual respiratory system models. Nanotechnology 2006: Toxicology of Nanoparticles. Abst. #. American Association for the Advancement of Science Annual Meeting. St. Louis, MO. February 17, 2006. (Invited)
Posted by
mak
on
Oct 31, 2006
— 280 views
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