Project Synopsis
| The overall objective of this research is to
develop state-of-the-art, biologically-based
computational models of the respiratory system
that couples high-performance supercomputing with
the latest imaging and experimental
advances. Using an interdisciplinary
bioengineering approach, we hope to achieve an
unprecedented level of detail in describing
structure-function relationships in the
respiratory system of laboratory animals and
humans. Our underlying philosophy centers on the
belief that highly detailed biologically based
computational models provide a unique basis for
integrating fundamental information about the
mammalian respiratory system into a quantitative,
understandable format that can readily be
interrogated to gain important new insights into
how interactions with the environment ultimately
affect both normal and potentially sensitive
individuals. |
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Reconstructed Airway Tree
| Magnetic resonance imaging of hyperpolarized 3-He
was used to create this 3D image of an airway
tree. The imaging was done on a live,
mechanically ventilated, 310 g rat. The airway
tree is rotated such that the trachea is vertical,
as if the rat was standing on his hind legs. |
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Published: An Automated Self-Similarity Analysis of the Pulmonary Tree...
Einstein, D. R., B. Neradilak, N. Pollisar, K. R. Minard, C. Wallis, M. Fanucchi, J. P. Carson, A. P. Kuprat, S. Kabilan, R. E. Jacob and R. A. Corley (2008). "An Automated Self-Similarity Analysis of the Pulmonary Tree of the Sprague-Dawley Rat." Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology 291(12): 1628-1648.
Read full article: 240 more words
Posted by
mak
on
Dec 31, 2008
— 485 views
Published: 3D He-3 diffusion MRI as a local in vivo morphometric tool...
Jacob, R. E., K. R. Minard, G. Laicher and C. Timchalk (2008). "3D He-3 diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs." Journal of Applied Physiology 105(4): 1291-1300.
Read full article: 184 more words
Posted by
mak
on
Dec 31, 2008
— 468 views
Published: MR imaging of apparent He-3 gas transport in narrow pipes and rodent
Minard, K. R., R. E. Jacob, G. Laicher, D. R. Einstein, A. P. Kuprat and R. A. Corley (2008). "MR imaging of apparent He-3 gas transport in narrow pipes and rodent airways." Journal of Magnetic Resonance 194(2): 182-191.
Read full article: 148 more words
Posted by
mak
on
Dec 31, 2008
— 397 views
Published: Mass transfer process in a two-region medium
Chastanet, J. and Wood, B.D. (2008). Mass transfer process in a two-region medium. Water Resources Res. 44, W05413, doi:10.1029/2006WR005553.
Read full article: 255 more words
Posted by
mak
on
Jun 10, 2008
— 710 views
Published: Subject-specific model estimation of cardiac output and blood...
Neal, M. L. and J. B. Bassingthwaighte (2007). Subject-specific model estimation of cardiac output and blood volume during hemorrhage. Cardiovasc Eng 7(3): 97-120.
Read full article: 225 more words
Posted by
mak
on
Jun 10, 2008
— 778 views
Published: Unsteady-state airflow and particle deposition in a three...
Nazridoust, K. and B. Asgharian (2008). Unsteady-state airflow and particle deposition in a three-generation human lung geometry. Inhal Toxicol 20(6): 595-610.
Read full article: 261 more words
Posted by
mak
on
Jun 10, 2008
— 766 views
Published - 3D MRI of non-Gaussian 3He gas diffusion in the rat lung
Posted by
mak
on
Oct 22, 2007
— 1272 views
Manuscript List and Links
Posted by
mak
on
Jun 14, 2007
— 1093 views
We've moved!
Posted by
mak
on
Feb 06, 2007
— 768 views
Abstract: Quantitative Magnetic Resonance Imaging of 3-He Gas Transport
R.E. Jacob and K.R. Minard, "Quantitative Magnetic Resonance Imaging of 3-He Gas Transport", American Physical Society March Meeting, Denver, CO. March 5-9, 2007.
Posted by
rejacob
on
Nov 20, 2006
— 779 views
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